|
KMID : 0903519980410040246
|
|
Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1998 Volume.41 No. 4 p.246 ~ p.250
|
|
|
Cytotoxic Activity of Leguminous Seed Extracts against Human Tumor Cell Lines
|
|
Lee, Hoi Seon
Lee, Jeong Ock/Ahn, Young Joon/Lee, Hee Kwon/Oh, Jong Hwan
|
|
|
Abstract
|
|
|
|
The cytotoxic activity of methanol extracts of 25 leguminous seeds in vitro was evaluated by sulforhodamine B assay, using the five human solid A549 lung, SK-OV-2 ovarian, SK-MEL-2 melanoma, XF-498 CNS and HCT-15 colon tumor cell lines. The responses varied with both cell line arid leguminous seed used. Extracts of Canavalia lineata and Glycine soja revealed potent cytotoxic activity against A549 arid SK-MEL-2 cell lines. Moderate activity was observed in the extracts of Cassia obtusifolia and Glyeine max var. chungtae, and C. lineata and Vigna angulasis against SK-MEL-2 and HCT-15 cell lines, respectively. The other seed extracts were ineffective against model tumor cell lines. Because of their potent cytotoxic activities, the activity of each solvent fraction from C. lineata and G. soja was determined and the potent activity was produced from their chloroform fractions. As a naturally occurring therapeutic agent, leguminous seeds described could be useful for developing new types of anti-tumor agents.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|